Neurobiology of Disease More Is Not Always Better: Increased Fractional Anisotropy of Superior Longitudinal Fasciculus Associated with Poor Visuospatial Abilities in Williams Syndrome
نویسندگان
چکیده
Fumiko Hoeft,1 Naama Barnea-Goraly,1 Brian W. Haas,1 Golijeh Golarai,1 Derek Ng,1 Debra Mills,2 Julie Korenberg,3,4 Ursula Bellugi,5 Albert Galaburda,6 and Allan L. Reiss1 1Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94305-5795, 2Department of Psychology, Emory University, Atlanta, Georgia 30322, 3Department of Pediatrics, Cedars Sinai Medical Center, Los Angeles, California 90048, 4Department of Human Genetics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095-7088, 5Laboratory for Cognitive Neuroscience, Salk Institute for Biological Studies, La Jolla, California 92037, and 6Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215
منابع مشابه
More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome.
We used diffusion tensor imaging to examine white matter integrity in the dorsal and ventral streams among individuals with Williams syndrome (WS) compared with two control groups (typically developing and developmentally delayed) and using three separate analysis methods (whole brain, region of interest, and fiber tractography). All analysis methods consistently showed that fractional anisotro...
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